As plastics, including microplastics, increasingly infiltrate freshwater and marine ecosystems, they pose serious risks to aquatic organisms, particularly those that are part of the human food chain. To address this crisis, researchers and policymakers require a multidisciplinary exploration of both the origins of plastic pollution and the potential mitigation strategies, including biodegradable alternatives, circular economy approaches, policy frameworks, and community-led efforts to reduce environmental impact. Plastic Tides: Tackling Plastic Pollution for Global Food Security will not only examine the sources of plastics in water bodies, their accumulation in aquatic food species, and the potential health and economic impacts on communities reliant on these resources, but also explore practical solutions, including plastic reduction strategies and sustainable material alternatives. Special emphasis will be placed on regions and populations that are particularly dependent on fisheries and agriculture, highlighting their heightened exposure and vulnerability. Insights from across the fields of environmental science, toxicology, and public health, together offer a comprehensive guide to tackling this influx of pollution on a scientific and public policy level.